(Z)-tert-butyl 1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamat synthesis
- Product Name:(Z)-tert-butyl 1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamat
- CAS Number:103421-61-0
- Molecular formula:C16H15N3O
- Molecular Weight:265.31
![benzyl (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate](/CAS/20180527/GIF/106849-47-2.gif)
106849-47-2
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103421-61-0
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Yield:103421-61-0 99%
Reaction Conditions:
with hydrogen bromide in acetic acid at 20; for 2 h;
Steps:
19
This compound (0.20 g, 0.50 mmol) was dissolved in 5.7 ml. of HBr (33% solution inAcOH) under N2 and the solution was kept stirring at room temperature for 2 hr, then diluted with Et2O (15 ml.) to obtain a suspension. The mixture was filtered and the solid dissolved in H2O. The aqueous solution was then made alkaline with Na2CO3 and extracted with AcOEt. The organic phase was dried (Na2SO4), the solvent was removed under vacuum obtaining the title compound in 99% yield. M.p. 62-64 0C.[1H]-NMR (CD3OD): 3.48 (s, 3H, Me); 4.43 (s, 1 H, CH); 7.26-7.32 (m, 2H), 7.39-7.46 (m, 2H), 7.47-7.54 (m, 1 H), 7.56-7.61 (m, 3H), 7.65-7.70 (m, 1 H) (aromatic protons) ppm.
References:
WO2009/81349,2009,A1 Location in patent:Page/Page column 21
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103373-62-2
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103421-61-0
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103343-47-1
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$40.00/50mg
74-88-4
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$15.00/10g
103421-61-0
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108895-98-3
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$60.00/100mg
103421-61-0
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![1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE](/CAS/GIF/3034-65-9.gif)
3034-65-9
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103421-61-0
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