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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
1035555-51-1

(R)-3-(2,3-DIHYDROXYPROPYL)-5-(2-FLUORO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-D]PYRIMIDINE-4,7(3H,8H)-DIONE synthesis

7synthesis methods
4-Pyrimidinol, 6-(methylamino)- (6CI,7CI,8CI)

1122-67-4
26 suppliers
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(R)-3-(2,3-DIHYDROXYPROPYL)-5-(2-FLUORO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-D]PYRIMIDINE-4,7(3H,8H)-DIONE

1035555-51-1
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Yield:-

Steps:

Multi-step reaction with 8 steps
1: potassium carbonate / ethanol
2: 1-methyl-pyrrolidin-2-one; diphenylether / 240 °C
3: trichlorophosphate
4: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane
5: acetic acid; zinc
6: hydrogenchloride; potassium iodide; sodium nitrite
7: ammonium formate; palladium(II) hydroxide / 1,4-dioxane
8: potassium carbonate / N,N-dimethyl-formamide

References:

Dong, Qing;Dougan, Douglas R.;Gong, Xianchang;Halkowycz, Petro;Jin, Bohan;Kanouni, Toufike;O'Connell, Shawn M.;Scorah, Nicholas;Shi, Lihong;Wallace, Michael B.;Zhou, Feng [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 5,p. 1315 - 1319]

1035556-23-0 Synthesis
3-Benzyl-5-hydroxy-8-methyl-3H,8H-pyrido[2,3-d]pyrimidine-4,7-dione

1035556-23-0
6 suppliers
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(R)-3-(2,3-DIHYDROXYPROPYL)-5-(2-FLUORO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-D]PYRIMIDINE-4,7(3H,8H)-DIONE

1035555-51-1
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References
3-BENZYL-5-(2-FLUORO-4-NITROPHENYLAMINO)-8-METHYLPYRIDO[2,3-D]PYRIMIDINE-4,7(3H,8H)-DIONE

1035556-25-2
4 suppliers
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(R)-3-(2,3-DIHYDROXYPROPYL)-5-(2-FLUORO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-D]PYRIMIDINE-4,7(3H,8H)-DIONE

1035555-51-1
4 suppliers
inquiry

References
3-Benzyl-6-methylamino-3H-pyrimidin-4-one

1035556-22-9
6 suppliers
inquiry

(R)-3-(2,3-DIHYDROXYPROPYL)-5-(2-FLUORO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-D]PYRIMIDINE-4,7(3H,8H)-DIONE

1035555-51-1
4 suppliers
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References
3-Benzyl-5-chloro-8-methyl-3H,8H-pyrido[2,3-d]pyrimidine-4,7-dione

1035556-24-1
5 suppliers
inquiry

(R)-3-(2,3-DIHYDROXYPROPYL)-5-(2-FLUORO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-D]PYRIMIDINE-4,7(3H,8H)-DIONE

1035555-51-1
4 suppliers
inquiry

References