7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine(WXC08077) synthesis
- Product Name:7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine(WXC08077)
- CAS Number:1037627-94-3
- Molecular formula:C15H22N2
- Molecular Weight:230.35
![1-(2-NITRO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-7-YL)PYRROLIDINE](/CAS/20200611/GIF/1037627-93-2.gif)
1037627-93-2
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1037627-94-3
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Yield:1037627-94-3 100%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol; under 2068.65 Torr; for 1 h;
Steps:
4
SYNTHETIC PREPARATION 4. Synthesis of 7-(pyrrolidin-1 -yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine Compound of formula (Ba). A mixture of 1-(2-nitro-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)pyrrolidine (2.0 g; 7.69 mmol) and 10% palladium on carbon (0.2 g, -50% water) in methanol (150 mL) was shaken under hydrogen (40 psi) for 1 h. After this time the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford 7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine as an oil (quantitative yield); MS (m/e): 231 (M+H+).
References:
WO2008/83367,2008,A2 Location in patent:Page/Page column 134
91-13-4
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1037627-94-3
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24790-66-7
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1037627-94-3
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![8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one](/CAS/GIF/37949-03-4.gif)
37949-03-4
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1037627-94-3
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![2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one](/CAS/20180713/GIF/740842-50-6.gif)
740842-50-6
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1037627-94-3
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