2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE synthesis
- Product Name:2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE
- CAS Number:1044870-30-5
- Molecular formula:C18H18N2O4
- Molecular Weight:326.35
2233-18-3
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Yield:1044870-30-5 79%
Reaction Conditions:
with toluene-4-sulfonic acid;sodium hydrogensulfite in N,N-dimethyl acetamide at 120; for 16 h;
Steps:
2-(4-hydroxy-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one(RVX-OH).
Aniline 12 (37 mg, 0.188 mmol) and4-hydroxy-3,5-dimethylbenzaldehyde (13a)(28.3 mg, 0.188 mmol) were dissolved inDMAc (1.0 mL) and treated with sodiumhydrogen sulfite (23.5mg, 0.23 mmol) and PTSA (7.2 mg, 0.04 mmol).The reactionmixture was stirred at 120 °C for 16 h. Water was added tothereaction, and the precipitated solid was collected by filtrationto giveRVX-OH (49 mg, 79%).
References:
Shao, Mingfeng;He, Linhong;Zheng, Li;Huang, Lingxiao;Zhou, Yuanyuan;Wang, Taijing;Chen, Yong;Shen, Mingsheng;Wang, Fang;Yang, Zhuang;Chen, Lijuan [Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,# 17,p. 4051 - 4055] Location in patent:supporting information
21544-81-0
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10272-07-8
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21577-57-1
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40891-33-6
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