4-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile synthesis
- Product Name:4-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile
- CAS Number:1055361-35-7
- Molecular formula:C19H11F3N2O4S
- Molecular Weight:420.36
67515-59-7
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Yield:-
Steps:
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 95 °C
2: piperidine; benzoic acid / toluene / 12 h / 130 °C
References:
Patch, Raymond J.;Searle, Lily L.;Kim, Alexander J.;De, Debyendu;Zhu, Xizhen;Askari, Hossein B.;O'Neill, John C.;Abad, Marta C.;Rentzeperis, Dionisios;Liu, Jianying;Kemmerer, Michael;Lin, Ling;Kasturi, Jyotsna;Geisler, John G.;Lenhard, James M.;Player, Mark R.;Gaul, Micheal D. [Journal of Medicinal Chemistry,2011,vol. 54,# 3,p. 788 - 808]
