3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione synthesis
- Product Name:3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
- CAS Number:1061604-41-8
- Molecular formula:C13H12N2O4
- Molecular Weight:260.2454
55289-05-9
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Yield:-
Steps:
Multi-step reaction with 4 steps
1: 1H-imidazole / dichloromethane / 16 h / 0 - 10 °C / Inert atmosphere
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / 80 °C / Inert atmosphere
3: triethylamine / acetonitrile / 16 h / 80 °C / Inert atmosphere
4: hydrogenchloride / water; acetonitrile; tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
References:
KYMERA THERAPEUTICS, INC.;MAINOLFI, Nello;JI, Nan;KLUGE, Arthur F.;WEISS, Matthew M.;ZHANG, Yi;ZHENG, Xiaozhang WO2020/113233, 2020, A1
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1061604-41-8
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