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4-Formyl-1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazole synthesis

2synthesis methods
60061-68-9 Synthesis
4-BROMO-3-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE

60061-68-9
85 suppliers
$15.00/1g

-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 18 h / 70 °C
2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.05 h / -78 °C
2.2: 2 h / -78 - 0 °C
2.3: 1 h / 20 °C

References:

ELI LILLY AND COMPANY WO2008/141020, 2008, A1