2-isopropoxy-6-(4-methylpiperazin-1-yl)pyridin-3-amine synthesis
- Product Name:2-isopropoxy-6-(4-methylpiperazin-1-yl)pyridin-3-amine
- CAS Number:1095033-59-2
- Molecular formula:C13H22N4O
- Molecular Weight:250.34
![1-methyl-4-[5-nitro-6-(propan-2-yloxy)pyridin-2-yl]piperazine](/CAS/20180703/GIF/1462950-98-6.gif)
1462950-98-6
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Yield:1095033-59-2 512 mg
Reaction Conditions:
with palladium 10% on activated carbon;ammonium formate in methanol at 80; for 0.0833333 h;Microwave irradiation;
Steps:
8.method 14 Method 14 6-(4-Methylpiperazin-1-yl)-2-(propan-2-yloxy)pyridin-3-amine
In a microwave tube, 500 mg of 1-methyl-4-[5-nitro-6-(propan-2-yloxy)pyridin-2-yl]piperazine are introduced into 15 ml of methanol. 675 mg of ammonium formate and 270 mg of Pd/C (10%) are added. The reaction medium is microwave-heated at 80° C. for 5 minutes. The mixture is filtered on Clarcel and the Clarcel is rinsed with methanol. The filtrate is concentrated under reduced pressure, so as to give 512 mg of 6-(4-methylpiperazin-1-yl)-2-(propan-2-yloxy)pyridin-3-amine in the form of a purple gum
References:
US2013/261106,2013,A1 Location in patent:Paragraph 0555
186413-77-4
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