ChemicalBook CAS DataBase List N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-4-(trifluoroMethyl)-BenzenesulfonaMide

N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-4-(trifluoroMethyl)-BenzenesulfonaMide synthesis

1synthesis methods

Product Name:N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-4-(trifluoroMethyl)-BenzenesulfonaMide
CAS Number:1105576-13-3
Molecular formula:C21H19F3N2O2S
Molecular Weight:420.45

2991-42-6 Synthesis

4-(Trifluoromethyl)benzene-1-sulfonyl chloride

2991-42-6
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$6.00/5g

35132-20-8 Synthesis

35132-20-8
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$7.00/1g

N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-4-(trifluoroMethyl)-BenzenesulfonaMide

1105576-13-3
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Yield:1105576-13-3 82%

Reaction Conditions:

in dichloromethane;1,2-dichloro-ethane at 0; for 4 h;

Steps:

20.1

(1)According to the method of step (1) in Preparation 1,the difference is,Using p-trifluoromethylphenylsulfonyl chloride (20 mmol, available from Kling 247070)Instead of p-methylphenylsulfonyl chloride and reacted at 0 ° C for 4 h,Thus, 16.4 mmol of the chiral diamine represented by the formula (R, R) - (3-1-1-6) was obtained in a yield of 82%

References:

CN107286089,2017,A Location in patent:Paragraph 0196-0197