ethyl {[(3-broMopyridin-2-yl)aMino]carbonothioyl}carbaMate synthesis
- Product Name:ethyl {[(3-broMopyridin-2-yl)aMino]carbonothioyl}carbaMate
- CAS Number:1124383-00-1
- Molecular formula:C9H10BrN3O2S
- Molecular Weight:304.16
13534-99-1
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Yield:1124383-00-1 99%
Reaction Conditions:
in 1,4-dioxane at 20;
Steps:
A15.a Preparation of intermediate 50
Ethoxycarbonyl isothiocyanate (25 g, 191 mmol) was added to a sol. of 2-amino-3- bromopyridine (28.68 g, 166 mmol) in 1,4-dioxane (500 mL). The r.m. was stirred at r.t. overnight. The solvent was evaporated in vacuo and the residue was suspended in DIPE. The precipitate was filtered off and dried in vacuo at 60 °C. Yield: 50 g of intermediate 50 (99% yield).
References:
WO2013/10904,2013,A1 Location in patent:Page/Page column 76