(2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide synthesis
- Product Name:(2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide
- CAS Number:113181-02-5
- Molecular formula:C12H10BrF3N2O2
- Molecular Weight:351.12
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Yield:113181-02-5 90%
Reaction Conditions:
with dichlorosulfoxide;triethylamine
Steps:
6 (S)-3-Bromo-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide(C12H9F3N2O2)
(S)-3-Bromo-2-hydroxy-2-methylpropanoic acid (1.00 g, 0.0054645 mol) reacted with thionyl chloride (0.78 g, 0.0065574 mol), trimethylamine (0.72 g, 0.0071038 mol), and 4-amino-2- (trifluoromethyl)benzonitrile (1.02 g, 0.0054645 mol) to afford the titled compound.The product was purified by a silica gel column using DCM and ethyl acetate (19:1) as eluent to afford 1.75 g (90%) of the titled compound as a yellowish solid.Mass (ESI, Positive): 351.08 [M+Na]+.
References:
WO2019/222556,2019,A1 Location in patent:Paragraph 00479-00481
75-09-2
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$60.00/10mg
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113181-02-5
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