([1,2,4]TRIAZOLO[3,4-B][1,3]BENZOTHIAZOL-3-YLTHIO)ACETIC ACID synthesis
- Product Name:([1,2,4]TRIAZOLO[3,4-B][1,3]BENZOTHIAZOL-3-YLTHIO)ACETIC ACID
- CAS Number:114722-63-3
- Molecular formula:C10H7N3O2S2
- Molecular Weight:265.31
79-11-8
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![2H-BENZO[4,5]THIAZOLO[2,3-C][1,2,4]TRIAZOLE-3-THIONE](/CAS/GIF/6957-85-3.gif)
6957-85-3
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114722-63-3
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$252.00/500mg
Yield:114722-63-3 85%
Reaction Conditions:
with sodium hydroxide in methanol;water; for 8 h;Reflux;
Steps:
3.2.5 Synthesis and characterization of s-triazolo[3,4-b]benzothiazol-3-ylthioacetic acid (6) by alkylation of 3 with chloroacetic acid
To the solution of s-triazolo[3,4-b]benzothiazole-3-thiol (3) (1.0 g, 4.8 mmol) in aqueous methanol (20 mL), sodium hydroxide (0.38 g, 4.8 mmol) and chloroacetic acid (0.45 g, 4.8 mmol) were added. The reaction mixture was refluxed for 8 h, cooled, filtered, and acidified with conc. HCl. The formed precipitate was filtered off, washed with cold water, and recrystallized from aqueous ethanol (1.1 g, 85.0% yield), m.p. 260-263 °C. 1H NMR (300 MHz, DMSO): δ 13.20-12.51 (H, brs, CO2H), 8.13 (1H, d, J = 8.1 Hz, ArH), 8.08 (1H, d, J = 8.1 Hz, ArH), 7.63-7.48 (2H, m, ArH), 4.03 (2H, s, SCH2). 13C NMR (75 MHz, DMSO): δ 169.1 (CO), 155.9, 142.4 (2SCN), 131.3, 129.3, 126.9, 126.3, 125.4, 114.2 (Ar-C), 35.8 (SCH2). IR (KBr, ν/cm-1) 3500-2600 (OH), 1725 (C=O, acid). Anal. Calcd. for C10H7N3O2S2 (265.31): C, 45.27; H, 2.66; N, 15.84; found: C, 45.38; H, 2.91; N, 15.89.
References:
Aboelmagd;Ali, Ibrahim A.I.;Salem, Ezzeldin M.S.;Abdel-Razik [European Journal of Medicinal Chemistry,2013,vol. 60,p. 503 - 511]
615-21-4
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114722-63-3
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$252.00/500mg
149-30-4
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114722-63-3
11 suppliers
$252.00/500mg
6957-85-3
26 suppliers
$45.00/50mg
114722-63-3
11 suppliers
$252.00/500mg
6957-85-3
26 suppliers
$45.00/50mg
3926-62-3
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$21.69/250g
114722-63-3
11 suppliers
$252.00/500mg