3-(Pyridin-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine synthesis
- Product Name:3-(Pyridin-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
- CAS Number:1159522-34-5
- Molecular formula:C10H11N5
- Molecular Weight:201.23
![1,2,4-Triazolo[4,3-a]pyrazine-7(8H)-carboxylic acid, 5,6-dihydro-3-(2-pyridinyl)-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/1254073-77-2.gif)
1254073-77-2
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1159522-34-5
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Yield:1159522-34-5 46%
Reaction Conditions:
Stage #1: tert-butyl 3-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazine-7(8H)-carboxylatewith trifluoroacetic acid in dichloromethane at 0 - 20; for 0.25 h;Inert atmosphere;
Stage #2: with water for 0.5 h;Inert atmosphere;
References:
Hoveyda, Hamid R.;Fraser, Graeme L.;Roy, Marie-Odile;Dutheuil, Guillaume;Batt, Frédéric;El Bousmaqui, Mohamed;Korac, Julien;Lenoir, Fran?ois;Lapin, Alexey;No?l, Sophie;Blanc, Sébastien [Journal of Medicinal Chemistry,2015,vol. 58,# 7,p. 3060 - 3082]
1452-63-7
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1159522-34-5
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