Carbamic acid, [(1R)-1-formyl-2-(methylthio)ethyl]-, 1,1-dimethylethyl ester synthesis

3synthesis methods

Product Name:Carbamic acid, [(1R)-1-formyl-2-(methylthio)ethyl]-, 1,1-dimethylethyl ester
CAS Number:116754-91-7
Molecular formula:C9H17NO3S
Molecular Weight:219.3

Carbamic acid, N-[(1R)-2-(methoxymethylamino)-1-[(methylthio)methyl]-2-oxoethyl]-, 1,1-dimethylethyl ester

144474-29-3
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Carbamic acid, [(1R)-1-formyl-2-(methylthio)ethyl]-, 1,1-dimethylethyl ester

116754-91-7
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Yield:-

Reaction Conditions:

with diisobutylaluminium hydride in dichloromethane at -78; for 0.666667 h;

Steps:

1M Bu)₂AlH (5.2 mL, 5.2 mmol) is added slowly to 1-152 (0.65 g, 2.3 mmol) and CH₂C1₂ (10 mL) at -78 C. The mixture is stirred at -78 for 40 min, 1M NaHS0₄ (5 mL) is added, the mixture is warmed to rt, and CH₂C1₂ (60 mL) and brine (10 mL) are added. The mixture is filtered through celite. The organic phase of the filtrate is dried over Na₂S0₄, filtered, and concentrated to provide 1-153 as an oil.

References:

WO2011/109470,2011,A1 Location in patent:Page/Page column 68

methylN-(tert-butoxycarbonyl)-S-methyl-L-cysteinate

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References

16947-80-1
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$19.00/250mg

116754-91-7
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References