4-{4-[2-(3,5-Dimethyl-phenyl)-pyrrolidin-1-ylmethyl]-phenoxy}-3-fluoro-benzamide synthesis
- Product Name:4-{4-[2-(3,5-Dimethyl-phenyl)-pyrrolidin-1-ylmethyl]-phenoxy}-3-fluoro-benzamide
- CAS Number:1174130-60-9
- Molecular formula:C26H27FN2O2
- Molecular Weight:418.5
676494-56-7
25 suppliers
inquiry
383127-44-4
59 suppliers
$115.00/50mg
1174130-60-9
5 suppliers
inquiry
Yield:1174130-60-9 69%
Reaction Conditions:
Stage #1: 3-fluoro-4-(4-formylphenoxy)benzamide;2-(3,5-dimethylphenyl)pyrrolidine in 1,2-dichloro-ethane at 20;Molecular sieve;
Stage #2: with sodium tris(acetoxy)borohydride;acetic acid in 1,2-dichloro-ethane at 20; for 3 h;
References:
Mitch, Charles H.;Quimby, Steven J.;Diaz, Nuria;Pedregal, Concepcion;De La Torre, Marta G.;Jimenez, Alma;Shi, Qing;Canada, Emily J.;Kahl, Steven D.;Statnick, Michael A.;McKinzie, David L.;Benesh, Dana R.;Rash, Karen S.;Barth, Vanessa N. [Journal of Medicinal Chemistry,2011,vol. 54,# 23,p. 8000 - 8012] Location in patent:experimental part
676494-55-6
26 suppliers
inquiry
1174130-60-9
5 suppliers
inquiry
64248-62-0
445 suppliers
$6.00/5g
1174130-60-9
5 suppliers
inquiry
123-08-0
952 suppliers
$5.00/10g
1174130-60-9
5 suppliers
inquiry