TERT-BUTYL 5-OXO-5H-SPIRO[FURO[3,4-B]PYRIDINE-7,4-PIPERIDINE]-1-CARBOXYLATE synthesis

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: 2,6-dimethylpyridine / dichloromethane / 3 h
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / N,N-dimethyl-formamide; water / 0.17 h / 100 °C / Microwave irradiation
3.1: water; sodium hydroxide / methanol / 24 h
4.1: iodine; potassium iodide; sodium hydrogencarbonate / water; acetonitrile / 15 h / 20 °C
5.1: 2,2'-azobis(isobutyronitrile) / toluene / 0.17 h / 80 °C
5.2: 3 h

References:

EP3480198,2019,A1