6-BROMO-2',3',5',6'-TETRAHYDROSPIRO[INDOLINE-3,4'-PYRAN]-2-ONE synthesis
- Product Name:6-BROMO-2',3',5',6'-TETRAHYDROSPIRO[INDOLINE-3,4'-PYRAN]-2-ONE
- CAS Number:1190861-43-8
- Molecular formula:C12H12BrNO2
- Molecular Weight:282.13
![tert-butyl 6-bromo-2-oxo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-1-carboxylate](/CAS/20180601/GIF/1190861-47-2.gif)
1190861-47-2
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1190861-43-8
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Yield:1190861-43-8 98%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20; for 5 h;
Steps:
8.c
A mixture of tert-butyl 6-bromo-2-oxo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-1-carboxylate (preparation 8b, 4.20 g, 11.0 mmol) and a 5M solution of hydrogen chloride in 1,4-dioxane (25 mL) was stirred at room temperature. After 5 hours, the mixture was concentrated in vacuo to give the title compound (3.20 g, 98%) as a pale pink solid. LRMS (m/z): 278/280 (M-1)+. 1H-NMR δ (DMSO-d6): 1.71 (m, 4H), 3.81 (m, 2H), 4.01 (m, 2H), 6.98 (d, J=1.65 Hz, 1H), 7.14 (dd, J=7.97 Hz, J=1.65 Hz, 1H), 7.47 (d, J=7.97 Hz, 1H), 10.55 (s, NH).
References:
EP2108641,2009,A1 Location in patent:Page/Page column 32-33
1202765-53-4
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1190861-43-8
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5414-19-7
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1190861-43-8
40 suppliers
$503.26/5MG
5414-19-7
199 suppliers
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1190861-43-8
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$503.26/5MG
34270-90-1
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99365-40-9
315 suppliers
$6.00/1g
1190861-43-8
40 suppliers
$503.26/5MG