2-Chloro-4-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine synthesis

Yield:1192711-79-7 94%

Reaction Conditions:

in dimethyl sulfoxide at 20; for 2 h;

Steps:

33a Synthesis example No. 33: preparation of: 2-(4-(2-(3-fluoro-4-methoxvphenyl}-4-(methylsulfonyi}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acetic acid (compound No. 57)33a): 2-ch/oro-4-(methy/thio)-7H-pyrrolo[2,3-d]pyrimidine

To a stirring solution of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (0.1 g, 0.53 mmol) in DMSO (0.7 ml) at RT was added sodiumthiomethoxide (0.045 g, 0.64 mmol, 1.2 eq) and the mixture was stirred at RT for 2 h. Then water was added to induce precipitation. The precipitate was collected and dried under vacuum to give 2-chloro-4-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine (0.1 g, 94%) as an off white solid.

References:

WO2015/18534,2015,A1 Location in patent:Page/Page column 48