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ChemicalBook CAS DataBase List 1H-Isoindole-1,3(2H)-dione, 2-[(2S)-2,3-dihydroxypropyl]-
119835-88-0

1H-Isoindole-1,3(2H)-dione, 2-[(2S)-2,3-dihydroxypropyl]- synthesis

3synthesis methods
1H-Isoindol-1-one, 3-hydroxy-

136918-14-4
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57090-45-6 Synthesis
(R)-(-)-3-Chloro-1,2-propanediol

57090-45-6
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1H-Isoindole-1,3(2H)-dione, 2-[(2S)-2,3-dihydroxypropyl]-

119835-88-0
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Yield:119835-88-0 94.9%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 110; for 5 h;Gabriel Amine Synthesis;Reagent/catalyst;Temperature;Time;

Steps:

1 Example 1
110 g (1.0 mol) of R-chloroglycerol was added to the four-necked flask.174 g (1.0 mol) of phthalimide, 138 g (1.0 mol) of potassium carbonate and 550 mL of DMF, heated to 110 ° C, stirred, and reacted for 5 hours.After the reaction was completed, the reaction solution was cooled to 25 ° C.The reaction was dropped into 2.75 L of water, stirred for 2 hours, and filtered.Dry at 70 ° C to 209 g(S)-2-(2,3-dihydroxy-propyl)-isoindole-1,3-dione (formula VI),The yield was 94.9%.

References:

Haizheng Pharmaceutical Nantong Co., Ltd.;Zhejiang Haizheng Pharmaceutical Co., Ltd.;Xu Weiwei;Lu Yingxun;Chen Shengyu;Han Feng CN108586313, 2018, A Location in patent:Sheet 0055; 0056; 0059; 0062; 0065; 0068; 0071; 0074

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