1H-Isoindole-1,3(2H)-dione, 2-[(2S)-2,3-dihydroxypropyl]- synthesis
- Product Name:1H-Isoindole-1,3(2H)-dione, 2-[(2S)-2,3-dihydroxypropyl]-
- CAS Number:119835-88-0
- Molecular formula:C11H11NO4
- Molecular Weight:221.21
Yield:119835-88-0 94.9%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 110; for 5 h;Gabriel Amine Synthesis;Reagent/catalyst;Temperature;Time;
Steps:
1 Example 1
110 g (1.0 mol) of R-chloroglycerol was added to the four-necked flask.174 g (1.0 mol) of phthalimide, 138 g (1.0 mol) of potassium carbonate and 550 mL of DMF, heated to 110 ° C, stirred, and reacted for 5 hours.After the reaction was completed, the reaction solution was cooled to 25 ° C.The reaction was dropped into 2.75 L of water, stirred for 2 hours, and filtered.Dry at 70 ° C to 209 g(S)-2-(2,3-dihydroxy-propyl)-isoindole-1,3-dione (formula VI),The yield was 94.9%.
References:
Haizheng Pharmaceutical Nantong Co., Ltd.;Zhejiang Haizheng Pharmaceutical Co., Ltd.;Xu Weiwei;Lu Yingxun;Chen Shengyu;Han Feng CN108586313, 2018, A Location in patent:Sheet 0055; 0056; 0059; 0062; 0065; 0068; 0071; 0074
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