(4R,12aS)-7-(benzyloxy)-4-Methyl-3,4-dihydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-6,8(12H,12aH)-dione synthesis
- Product Name:(4R,12aS)-7-(benzyloxy)-4-Methyl-3,4-dihydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-6,8(12H,12aH)-dione
- CAS Number:1206102-09-1
- Molecular formula:C19H20N2O4
- Molecular Weight:340.37
61477-40-5
425 suppliers
$15.00/1g
1206102-08-0
35 suppliers
$465.00/1g
1206102-09-1
23 suppliers
$1131.00/1g
Yield: 96%
Reaction Conditions:
with acetic acid in toluene at 90; for 3.5 h;
Steps:
1.6
(6) 10 g of intermediate 6, 3.3 g of (R)-3-amino-butan-1-ol and 10 mL of glacial acetic acid were added to 100 mL of toluene,The mixture was stirred at 90 ° C for 3.5 hours, and the reaction was completed.The toluene solvent was distilled off, and 50 mL of dichloromethane was added to the system, and 50 mL×3 of water was extracted.The organic phase is dried, filtered,Concentration gave 10 g of a white solid, Intermediate 7. Yield: 96%.
References:
FUREN PHARMACEUTICAL GROUP XIDELONG CANCER DRUG CO LTD;Furen Pharmaceutical Group Xidelong Tumor Medicine Co., Ltd.;KAIFENG PHARMACEUTICAL GROUP CO LTD;Kaifeng Pharmaceutical (Group) Co., Ltd.;HENAN FUREN MEDICAL TECH DEVELOPMENT CO LTD;Henan Furen Pharmaceutical Development Co., Ltd.;LI XUGUANG;Li Xuguang;CHEN SHUIKU;Chen Shuiku;ZHU SONGLIN;Zhu Songlin;ZHANG FANGJIE;Zhang Fangjie;FANG SHUIXIA;Fang Shuixia;LIU CONGJUN;Liu Congjun;ZHU HUIFENG;Zhu Huifeng;LUO QI;Luo Qi;MENG QINGLE;Meng Qingle;CUI HAO;Cui Hao CN108299466, 2018, A Location in patent:Paragraph 0032; 0038
118-71-8
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$5.00/25mg
1206102-09-1
23 suppliers
$1131.00/1g
61049-69-2
84 suppliers
$68.00/25 mg
1206102-09-1
23 suppliers
$1131.00/1g
100-39-0
419 suppliers
$10.00/10 g
1206102-09-1
23 suppliers
$1131.00/1g
![2-(2-hydroxy-2-phenylethyl)-3-[(phenylmethyl)oxy]-4H-pyran-4-one](/CAS/20180703/GIF/1206102-04-6.gif)
1206102-04-6
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inquiry
1206102-09-1
23 suppliers
$1131.00/1g