N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea synthesis
- Product Name:N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea
- CAS Number:1217436-37-7
- Molecular formula:C23H19F6N3S
- Molecular Weight:483.47
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Yield:1217436-37-7 50%
Reaction Conditions:
Stage #1: (S,S)-1,2-diphenyl-1,2-diaminoethanewith hydrogenchloride in diethyl ether; for 1 h;Schlenk technique;Inert atmosphere;
Stage #2: 3,5-bistrifluoromethylphenylisothiocyanate in diethyl ether at 20; for 48 h;Schlenk technique;Inert atmosphere;
References:
N?dling, Alexander R.;Jakab, Gergely;Schreiner, Peter R.;Hilt, Gerhard [European Journal of Organic Chemistry,2014,vol. 2014,# 29,p. 6394 - 6398] Location in patent:supporting information