6-Bromo-8-ethyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one synthesis
- Product Name:6-Bromo-8-ethyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
- CAS Number:1232030-40-8
- Molecular formula:C20H23BrN6O
- Molecular Weight:443.34
16153-81-4
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![6-Bromo-8-ethyl-2-methylsulfinylpyrido[2,3-d]pyrimidin-7-one](/CAS/20180629/GIF/1286738-62-2.gif)
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Yield:1232030-40-8 40%
Reaction Conditions:
at 120; for 3 h;
Steps:
1.2
Step 2: Synthesis of 6-bromo-8-ethyl-2-[4-(4-methyl-piperazin-l-yl)- phenylamino] -8H-pyrido [2,3-d] pyrimidin-7-one (5).[00385] 6-Bromo-8-ethyl-2-methanesulfinyl-8H-pyrido[2,3-d]pyrimidin-7-one (4, 600 mg, 1.90 mmol) and 4-(4-methylpiperazino)aniline (363 mg, 1.90 mmol) were stirred at 120 °C for 3 h. The reaction mixture was purified by column chromatography usingdichloromethane: methanol (100:3→100:5) to give the title compound (340 mg, 0.77 mmol, 40 %) as a yellow solid. ESMS m/z 443 (M+H)+; 1H NMR (400 MHz, CDC13) δ ppm 8.47 (s, 1H) 7.92 (s, 1H) 7.51 (d, J= 8.8Hz, 2H) 7.24 (br. s., 1H) 6.96 (d, J= 8.8Hz, 2H) 4.48 (q, J= 7.0Hz, 2H) 3.13 - 3.29 (m, 4H) 2.53 - 2.64 (m, 4H) 2.36 (s, 3H) 1.35 (t, J= 7.0 Hz, 3H).
References:
WO2011/156646,2011,A2 Location in patent:Page/Page column 135
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211244-81-4
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![6-Bromo-8-ethyl-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one](/CAS/20180703/GIF/1232030-55-5.gif)
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