1-Piperidinecarboxylic acid, 4-(aminomethyl)-3-methyl-, 1,1-dimethylethyl ester synthesis
- Product Name:1-Piperidinecarboxylic acid, 4-(aminomethyl)-3-methyl-, 1,1-dimethylethyl ester
- CAS Number:1236121-41-7
- Molecular formula:C12H24N2O2
- Molecular Weight:228.33
1236121-40-6
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1236121-41-7
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Yield:1236121-41-7 54%
Reaction Conditions:
Stage #1: N-Boc-3-methylpiperidine-4-carboxamidewith lithium aluminium tetrahydride in tetrahydrofuran at -78 - 20;
Stage #2: with Glauber's salt
References:
Budzik, Brian;Garzya, Vincenzo;Shi, Dongchuan;Walker, Graham;Lauchart, Yann;Lucas, Adam J.;Rivero, Ralph A.;Langmead, Christopher J.;Watson, Jeannette;Wu, Zining;Forbes, Ian T.;Jin, Jian [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 12,p. 3545 - 3549] Location in patent:scheme or table