9,15-DIOXO-11ALPHA-HYDROXY-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC-17,17,18,18,19,19-D6 ACID synthesis
- Product Name:9,15-DIOXO-11ALPHA-HYDROXY-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC-17,17,18,18,19,19-D6 ACID
- CAS Number:1240398-16-6
- Molecular formula:C16H24O7
- Molecular Weight:328.36
![Cyclopentaneoctanoic-α,α,β,β,γ,γ-d6 acid, 2-(2-carboxyethyl)-ε,3-dioxo-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, (1R,2R,5R)-](/CAS/20211123/GIF/1352751-92-8.gif)
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1240398-16-6
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Yield:1240398-16-6 40%
Reaction Conditions:
with acetic acid in tetrahydrofuran;water; for 48 h;
Steps:
3
Preparation of Tetranor PGAM (27(B)) from Tetranor PGEM (26B-l a(iii))27B45 mg (0.11 mmol) of protected tetranor PGEM 26B-la(iii);- 5 ml of HOAc/THF/H20 (4:2: 1) mixture.[0076] A solution of protected tetranor PGEM 26B-1 a(iii) (in 5 ml ofHOAc/THF/H20 (4:2: 1)) was stirred for two days and evaporated with toluene. The remaining residue (40 mg) was purified by flash chromatography: Silica gel (20 g), hexane- ethyl acetate - HOAc 25:75:0.5 - hexane - ethyl acetate - HO Ac 10:90:0.5. The mass of the collected product (Tetranor PGAM (27(B))) was 14 mg (40%). Rf= 0.45 (ethanol - ethyl acetate - HOAc 5:95: 1).
References:
WO2011/159740,2011,A2 Location in patent:Page/Page column 30
1352751-84-8
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1240398-16-6
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1219794-58-7
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1240398-16-6
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![Hexanoic-3,3,4,4,5,5-d6 acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, methyl ester](/CAS/20211123/GIF/1352751-85-9.gif)
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1240398-16-6
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![Phosphonic acid, P-[7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-oxoheptyl-4,4,5,5,6,6-d6]-, dimethyl ester](/CAS/20211123/GIF/1352751-86-0.gif)
1352751-86-0
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1240398-16-6
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$261.00/25μg