2-amino-6-(trifluoromethyl)-1H-indole-3-carbonitrile synthesis
1synthesis methods
- Product Name:2-amino-6-(trifluoromethyl)-1H-indole-3-carbonitrile
- CAS Number:1242140-69-7
- Molecular formula:C10H6F3N3
- Molecular Weight:225.17
Yield:1242140-69-7 93%
Reaction Conditions:
Stage #1: N-[2-bromo-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroacetamide;malononitrilewith potassium carbonate;L-proline in water;dimethyl sulfoxide; for 0.25 h;Inert atmosphere;Ullmann type coupling;
Stage #2: with copper(l) iodide in water;dimethyl sulfoxide at 60; for 9 h;Inert atmosphere;Ullmann type coupling;
References:
Yang, Xiaobo;Fu, Hua;Qiao, Renzhong;Jiang, Yuyang;Zhao, Yufen [Advanced Synthesis and Catalysis,2010,vol. 352,# 6,p. 1035 - 1038] Location in patent:supporting information; experimental part