7-Amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid 1,1-dimethylethyl ester synthesis

4synthesis methods

Product Name:7-Amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid 1,1-dimethylethyl ester
CAS Number:1250998-24-3
Molecular formula:C11H20N2O3
Molecular Weight:228.29

tert-Butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate

1408075-90-0
64 suppliers
$23.00/100mg

7-Amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid 1,1-dimethylethyl ester

1250998-24-3
22 suppliers
$320.00/100mg

Yield:1250998-24-3 53%

Reaction Conditions:

Stage #1: tert-butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylatewith titanium(IV) isopropylate;ammonia in methanol at 0 - 20;Inert atmosphere;
Stage #2: with sodium tetrahydroborate in methanol at 0; for 3 h;Inert atmosphere;

References:

Li, Dong Bo;Rogers-Evans, Mark;Carreira, Erick M. [Organic Letters,2013,vol. 15,# 18,p. 4766 - 4769] Location in patent:supporting information

398489-26-4 Synthesis

398489-26-4
423 suppliers
$9.00/5g

1250998-24-3
22 suppliers
$320.00/100mg

References

2-Tert-Butyl 8-Ethyl 7-Oxo-5-Oxa-2-Azaspiro[3.4]Octane-2,8-Dicarboxylate

1453315-80-4
15 suppliers
inquiry

1250998-24-3
22 suppliers
$320.00/100mg

References

3-Ethoxycarbonylmethylene-azetidine-1-carboxylic acid tert-butyl ester

1002355-96-5
91 suppliers
$31.00/100mg

1250998-24-3
22 suppliers
$320.00/100mg

References