7-Amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid 1,1-dimethylethyl ester synthesis
- Product Name:7-Amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid 1,1-dimethylethyl ester
- CAS Number:1250998-24-3
- Molecular formula:C11H20N2O3
- Molecular Weight:228.29
![tert-Butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate](/CAS/20140602/GIF/CB92699269.gif)
1408075-90-0
75 suppliers
$23.00/100mg
1250998-24-3
29 suppliers
$320.00/100mg
Yield:1250998-24-3 53%
Reaction Conditions:
Stage #1: tert-butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylatewith titanium(IV) isopropylate;ammonia in methanol at 0 - 20;Inert atmosphere;
Stage #2: with sodium tetrahydroborate in methanol at 0; for 3 h;Inert atmosphere;
References:
Li, Dong Bo;Rogers-Evans, Mark;Carreira, Erick M. [Organic Letters,2013,vol. 15,# 18,p. 4766 - 4769] Location in patent:supporting information
398489-26-4
442 suppliers
$9.00/5g
1250998-24-3
29 suppliers
$320.00/100mg
![2-Tert-Butyl 8-Ethyl 7-Oxo-5-Oxa-2-Azaspiro[3.4]Octane-2,8-Dicarboxylate](/CAS/20180527/GIF/1453315-80-4.gif)
1453315-80-4
17 suppliers
inquiry
1250998-24-3
29 suppliers
$320.00/100mg
1002355-96-5
102 suppliers
$31.00/100mg
1250998-24-3
29 suppliers
$320.00/100mg