6-(BROMOMETHYL)-4-CHLORO-7-METHOXYQUINOLINE-3-CARBONITRILE synthesis

3synthesis methods

Product Name:6-(BROMOMETHYL)-4-CHLORO-7-METHOXYQUINOLINE-3-CARBONITRILE
CAS Number:1259017-81-6
Molecular formula:C12H8BrClN2O
Molecular Weight:311.56

16452-01-0 Synthesis

16452-01-0
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6-(BROMOMETHYL)-4-CHLORO-7-METHOXYQUINOLINE-3-CARBONITRILE

1259017-81-6
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: toluene / 5 h / Reflux
2: Dowtherm A / 24 h / Reflux
3: trichlorophosphate; N,N-dimethyl-formamide / 2 h / Reflux
4: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 0.5 h / Reflux

References:

Zhang, Xin;Li, Ridong;Qiao, Kang;Ge, Zemei;Zhang, Liangren;Cheng, Tieming;Li, Runtao [Archiv der Pharmazie,2013,vol. 346,# 1,p. 44 - 52]

4-CHLORO-7-METHOXY-6-METHYLQUINOLINE-3-CARBONITRILE

1259017-80-5
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1259017-81-6
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References

4-HYDROXY-7-METHOXY-6-METHYLQUINOLINE-3-CARBONITRILE

1259017-79-2
6 suppliers
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1259017-81-6
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References