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ChemicalBook CAS DataBase List (R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
1268524-71-5

(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 23 °C
2.1: piperidine / N,N-dimethyl-formamide / 23 °C
2.2: 90 °C
3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 - -10 °C
3.2: 0.75 h / -78 - -10 °C
4.1: tetrahydrofuran; butan-1-ol / 2 h / 20 - 90 °C

References:

Syeda, Shameem Sultana;Jakkaraj, Sudhakar;Georg, Gunda I. [Tetrahedron Letters,2015,vol. 56,# 23,p. 3454 - 3457]

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1268524-70-4 Synthesis
(+)-JQ-1

1268524-70-4
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Butanoic acid, 4-[[3-(4-chlorobenzoyl)-4,5-diMethyl-2-thienyl]aMino]-3-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]-4-oxo-, 1,1-diMethylethyl ester, (3S)-

1268524-65-7
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1268524-70-4 Synthesis
(+)-JQ-1

1268524-70-4
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Butanoic acid, 3-aMino-4-[[3-(4-chlorobenzoyl)-4,5-diMethyl-2-thienyl]aMino]-4-oxo-, 1,1-diMethylethyl ester, (3S)-

1268524-66-8
7 suppliers
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1268524-70-4 Synthesis
(+)-JQ-1

1268524-70-4
244 suppliers
$39.00/1mg

(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate Related Search: