ChemicalBook CAS DataBase List 2-Chloro-4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidine

2-Chloro-4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidine synthesis

7synthesis methods

Product Name: 2-Chloro-4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidine
CAS Number:1269440-58-5
Molecular formula:C10H10ClIN4
Molecular Weight:348.57

1269440-57-4 Synthesis

4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl) pyrimidin-2-ol

1269440-57-4
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2-Chloro-4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidine

1269440-58-5
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Yield:-

Reaction Conditions:

Stage #1: 4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-olwith trichlorophosphate at 110; for 16 h;
Stage #2: with sodium hydrogencarbonate in water;Product distribution / selectivity;

Steps:

[00159] Intermediate. 2-Chloro-4-(3-iodo- 1-isopropyl- lH-pyrazol-4-yl)pyrimidine [00160] A solution of Intermediate 4-(3-iodo- 1-isopropyl- lH-pyrazol-4- yl)pyrimidin-2-ol (438 mg, 1.33 mmol) in phosphorous oxychloride (10 ml) was heated at 110 ⁰C for 16 h. The mixture was concentrated under vacuum, then aqueous sodium bicarbonate solution was carefully added and the mixture was extracted with ethyl acetate. The combined organic extracts were dried over sodium sulfate, filtered, and concentrated to provide the title compound as a yellow solid. MS m/z 349.0 (M + 1).

References:

WO2011/25927,2011,A1 Location in patent:Page/Page column 43-44

89897-29-0 Synthesis