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ChemicalBook CAS DataBase List 3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-
127199-27-3

3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo- synthesis

2synthesis methods
3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-,ethyl ester

127199-25-1

3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-

127199-27-3

Ethyl 8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-ethyl-1,4-dihydroquinoline-3-carboxylate (Compound 3, 12.4 g, 34.3 mmol) was used as raw material. Compound 3 was dissolved in a mixture of hydrochloric acid (125 mL) and acetic acid (125 mL). The reaction mixture was stirred at 120-130°C for 2 hours. After completion of the reaction, the reaction solution was diluted with deionized water (500 mL) and the precipitate was collected by filtration. The precipitate was washed sequentially with deionized water and ether and then dried under reduced pressure to afford the target product 8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (Compound 4, 8.72 g, 76.2% yield) as a colorless solid.

101987-86-4 Synthesis
ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

101987-86-4
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: acetic anhydride / 1.5 h / 110 - 120 °C
1.2: 1 h / 20 °C
2.1: sodium hydride / 1,4-dioxane / 1 h
3.1: hydrogenchloride; acetic acid / water / 120 - 130 °C

References:

Liu, Yu;Liu, Lianxin;Shi, Guangxia [Asian Journal of Chemistry,2014,vol. 26,# 20,p. 7049 - 7051]

3-Quinolinecarboxylic acid, 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo- Related Search: