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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List (3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine
1276110-38-3

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine synthesis

9synthesis methods
940890-90-4 Synthesis
(S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE

940890-90-4
42 suppliers
$68.00/250mg

151266-23-8 Synthesis
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

151266-23-8
352 suppliers
$22.00/1g

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

1276110-38-3
57 suppliers
$18.00/100mg

-

Yield: 79%

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 80;Inert atmosphere;

Steps:

1.B.4 Step 4: Preparation of (R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d] pyrimidin-1-yl) piperidine-1-carboxylic acid tert-butyl ester
The 3-iodo--1H- pyrazolo [3,4-d] pyrimidin-4-ylamine (4.3g, 16.57mM, 1.0equiv) was dissolved in N, N- dimethylformamide (60mL),And cesium carbonate were sequentially added (6.753g, 35mM, 2.1equiv), (S) -3- (methanesulfonyloxy) piperidine-l-carboxylate (5.549g,19.88mM, 1.2equiv), and heated at 80 in nitrogen, after completion of the reaction by TLC, concentrated under reduced pressure most of the N, N- dimethylFormamide, was added water (60mL), and extracted with ethyl acetate (3 × 30), and the combined organic layers were washed with water, normal saline. The organic layer wasDried over anhydrous sodium sulfate, filtered and concentrated. Column chromatography (petroleum ether: ethyl acetate = 2: 1) to give a white solid after treatment Compound 4 (5.8g,79%).

References:

Chengdu Biological Technology Co. Ltd.;Li, De Qun CN105315283, 2016, A Location in patent:Paragraph 0015; 0016; 0017

151266-23-8 Synthesis
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

151266-23-8
352 suppliers
$22.00/1g

143900-44-1 Synthesis
(S)-1-Boc-3-hydroxypiperidine

143900-44-1
549 suppliers
$5.00/1g

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

1276110-38-3
57 suppliers
$18.00/100mg

References
1353993-49-3 Synthesis
(S)-3-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester

1353993-49-3
10 suppliers
$350.00/1 g

151266-23-8 Synthesis
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

151266-23-8
352 suppliers
$22.00/1g

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

1276110-38-3
57 suppliers
$18.00/100mg

References
151266-23-8 Synthesis
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

151266-23-8
352 suppliers
$22.00/1g

(R)-1-Boc-3-Hydroxypiperidine

143900-43-0
284 suppliers
$6.00/1g

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

1276110-38-3
57 suppliers
$18.00/100mg

References
570409-85-7 Synthesis
3-Iodo-3H-pyrazolo[3,4-d]pyriMidin-4-aMine

570409-85-7
20 suppliers
inquiry

143900-44-1 Synthesis
(S)-1-Boc-3-hydroxypiperidine

143900-44-1
549 suppliers
$5.00/1g

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

1276110-38-3
57 suppliers
$18.00/100mg

References