6-HYDROXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE synthesis
- Product Name:6-HYDROXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
- CAS Number:128073-50-7
- Molecular formula:C12H16ClNO3
- Molecular Weight:257.71
924-44-7
272 suppliers
$12.00/5g
3458-98-8
84 suppliers
$50.00/100mg
128073-50-7
47 suppliers
$45.00/100mg
Yield:128073-50-7 90%
Reaction Conditions:
in ethanol;toluene; for 18 h;Reflux;
Steps:
1.2
A solution of 3-(2-aminoethyl)phenol hydrochloride (4.60 g, 26.49 mmol) and 47% ethyl glyoxylate (6.15 mL, 29.14 mmol) in a mixed solvent of toluene/EtOH (50 mL) was heated under reflux for 18 hr. The reaction mixture was concentrated under reduced pressure. The precipitate was collected by filtration, and washed with ethyl acetate/diethyl ether to give ethyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylate hydrochloride (6.15 g, 23.86 mmol, 90%) as white crystals
References:
TW2016/2105,2016,A Location in patent:Paragraph 0549