(E)-N-(4-chlorobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide synthesis

3synthesis methods

Product Name:(E)-N-(4-chlorobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide
CAS Number:1284275-59-7
Molecular formula:C17H12Cl2N4O
Molecular Weight:359.21

890012-50-7 Synthesis

3-(4-CHLOROPHENYL)-1H-PYRAZOLE-5-CARBOHYDRAZIDE

890012-50-7
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104-88-1 Synthesis

104-88-1
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$5.00/25g

(E)-N-(4-chlorobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide

1284275-59-7
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Yield:1284275-59-7 60%

Reaction Conditions:

with acetic acid in methanol; for 6 h;Reflux;

Steps:

General procedure for the synthesis of hydrazones (4a-j)

General procedure: The hydrazones were prepared by condensation of hydrazide (10.0 mmol) and the appropriate aromatic aldehyde (10.5 mmol), in 55 ml of mixture of glacial CH₃COOH:CH₃OH (5:50) under reflux for 6 h. After cooling, the crude product was collected by filtration, washed and crystallized from hot ethanol to give a hydrazone (4a-j).

References:

Pathak, Ravindra B.;Chovatia;Parekh [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 15,p. 5129 - 5133] Location in patent:supporting information; experimental part

ETHYL 4-(4-CHLOROPHENYL)-2,4-DIOXOBUTANOATE

5814-38-0
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$28.60/10MG

1284275-59-7
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References

99-91-2 Synthesis

99-91-2
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$10.00/25g

1284275-59-7
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References