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ChemicalBook CAS DataBase List 1-[3-(3,4-dimethoxyphenyl)prop-2-enoyl]piperidin-2-one

1-[3-(3,4-dimethoxyphenyl)prop-2-enoyl]piperidin-2-one synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: triethylamine / tetrahydrofuran / 0.75 h / -20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere

References:

Meegan, Mary J.;Nathwani, Seema;Twamley, Brendan;Zisterer, Daniela M.;O'Boyle, Niamh M. [European Journal of Medicinal Chemistry,2017,vol. 125,p. 453 - 463]

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