Folate-PEG3-Azide synthesis
- Product Name:Folate-PEG3-Azide
- CAS Number:1313026-32-2
- Molecular formula:C27H35N11O8
- Molecular Weight:641.6357
![L-Glutamine, N2-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester](/CAS/20211123/GIF/1391826-59-7.gif)
1391826-59-7
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1313026-32-2
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Yield:1313026-32-2 52.5 g
Reaction Conditions:
with trifluoroacetic acid in dichloromethane;Inert atmosphere;
Steps:
88 Preparation of compound 606:
Trifluoroacetic acid (2.12 kg, 18.6 mol) was added in one portion to a mixture of compound 605 (260 g, 373 mmol) in CH2CI2 (2.6 L) at 20 °C under nitrogen, and the mixture was stirred at 20 °C for 5 hrs. The reaction mixture was concentrated under reduced pressure and purified by HPLC (column: Agela DuraShell C18 250*80mm*10um; mobile phase: [water (lOrnM NH4HCO3)-MeOH]; B%: 5%-40%,20 min) to give afford compound 606 (52.5 g, 81.82 mmol, 21.96% yield) as a solid. (M+H) 642.80; IR: 2107 (N3 Bond).
References:
WO2022/93800,2022,A2 Location in patent:Paragraph 00874; 00879
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808741-97-1
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1313026-32-2
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84793-07-7
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$6.00/1g
1313026-32-2
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134179-38-7
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$39.20/100MG
1313026-32-2
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37793-53-6
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$127.00/50mg
1313026-32-2
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