(E)-3-(2-(1H-tetrazol-5-yl)vinyl)-6-fluoro-1H-indole synthesis
- Product Name:(E)-3-(2-(1H-tetrazol-5-yl)vinyl)-6-fluoro-1H-indole
- CAS Number:1316695-35-8
- Molecular formula:C11H8FN5
- Molecular Weight:229.21
399-51-9
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1316695-35-8
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: trichlorophosphate / 18 h / 0 - 20 °C / Inert atmosphere
1.2: 2 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine / methanol / 0.17 h / 20 °C / Inert atmosphere
2.2: 10 h / 150 °C / Inert atmosphere; Microwave irradiation
3.1: aluminum (III) chloride; sodium azide / tetrahydrofuran / 18 h / Inert atmosphere; Reflux
References:
Dolusic, Eduard;Larrieu, Pierre;Moineaux, Laurence;Stroobant, Vincent;Pilotte, Luc;Colau, Didier;Pochet, Lionel;Van Den Eynde, Benoit;Masereel, Bernard;Wouters, Johan;Frederick, Raphael [Journal of Medicinal Chemistry,2011,vol. 54,# 15,p. 5320 - 5334]
1316695-32-5
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1316695-35-8
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2795-41-7
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$7.00/250mg
1316695-35-8
70 suppliers
$45.00/1mg