2-Furancarboxylic acid, 5-bromo-3-chloro-, ethyl ester synthesis
- Product Name:2-Furancarboxylic acid, 5-bromo-3-chloro-, ethyl ester
- CAS Number:1323764-24-4
- Molecular formula:C7H6BrClO3
- Molecular Weight:253.48
6132-37-2
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Yield:1323764-24-4 748 mg
Reaction Conditions:
Stage #1: ethyl 5-bromofuran-2-carboxylatewith 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex in tetrahydrofuran at -78; for 0.5 h;Inert atmosphere;
Stage #2: with benzenesulfonyl chloride in tetrahydrofuran at -78 - 25;Inert atmosphere;regioselective reaction;
References:
Piller, Fabian M.;Knochel, Paul [Synthesis,2011,# 11,p. 1751 - 1758] Location in patent:experimental part