3-(AMINOMETHYL)-4-ETHYL-6-METHYLPYRIDIN-2(1H)-ONE HCL synthesis
- Product Name:3-(AMINOMETHYL)-4-ETHYL-6-METHYLPYRIDIN-2(1H)-ONE HCL
- CAS Number:1346576-04-2
- Molecular formula:C9H15ClN2O
- Molecular Weight:202.6812
1346576-05-3
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1346576-04-2
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Yield:1346576-04-2 86%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;dichloromethane at 0; for 0.166667 h;
Steps:
5.4
Step 43-(Aminomethy])-4-ethyl-6-methylpyridin-2(lH)-one hydrochloride3-(Amino methyl)-4-ethyl-6-methylpyridin-2(lH)-one, (5.6 g, 33 mmol) was suspended in DCM (560 mL) and the insoluble contents/particles were filtered. The filtrate was concentrated and dried. The residue was dissolved in DCM (10 mL) and 4 M HCI inl,4-dioxane (16 mL, 66 mmol) was added at 0 °C and stirred for 10 min, at which time the reaction mixture was concentrated under high- vacuum and dried. The resulting crude solid was triturated with hexane (150 mL) and filtered. The solid was dried under vacuum. Collected 3-(amino methyl)-4-ethyl-6-methylpyridin-2(lH)-one hydrochloride (5.9 g, 86%). ? NMR (400 MHz, DMSO-
References:
WO2011/140325,2011,A1 Location in patent:Page/Page column 146
763-93-9
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1346576-04-2
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4376-23-2
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1346576-04-2
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