2-(2-(4-methylthiazol-5-yl)ethoxy)-2-oxoethyl)triphenylphosphonium bromide synthesis

Yield:1352002-58-4 31%

Reaction Conditions:

in toluene at 20; for 48 h;

Steps:

3.b

Under an atmosphere of N₂, 2-(4-methylthiazol-5-yl)ethyl 2-bromoacetate (176 mg) and triphenylphosphine (175 mg) were dissolved in toluene (1.5 ml). The reaction mixture was stirred for 48 hours at room temperature. The resulting white precipitate was filtered, triturated with toluene, and purified by recrystallization from ethanol to give the final product (110 mg, 31% yield). ¹H NMR (400 MHz, D₂O) δ 8.63 (s, 1H), 7.60-7.85 (m, 15H), 5.65 (d, 2H, ³J=13.6 Hz), 4.22 (t, 2H, ³J=5.7 Hz), 2.93 (t, 2H, ³J=5.7 Hz), 2.13 (s, 3H).

References:

US2011/301180,2011,A1 Location in patent:Page/Page column 25