2-Pyridineacetic acid, 3-amino-5-bromo-, ethyl ester synthesis
- Product Name:2-Pyridineacetic acid, 3-amino-5-bromo-, ethyl ester
- CAS Number:1379312-86-3
- Molecular formula:C9H11BrN2O2
- Molecular Weight:259.1
1211540-74-7
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Yield:1379312-86-3 71%
Reaction Conditions:
with iron;ammonium chloride in ethanol at 80; for 3 h;
Steps:
11.2 Step 2: ethyl 2-(3 -amino-S -bromopyridin-2-yl)acetate(B5 3-4)
In a suspension of B53-3 (4.1 g, 14.2 mmol) and saturated aqueous NH4C1 (20 mL) in 20 mL of EtOH was slowly added Fe (2.4 g, 42.5 mmol) at room temperature. The mixture was stirred at 80 °C for 3h. The reaction was filtered and extracted with DCM (10 mL * 3). The organic layers were dried over Na2504, filtered and concentrated. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 5/1) to give the title compound as a yellow oil (550 mg, 71 %). ‘H NMR (400 MHz, CDC13) ? 8.02 (s, 1H), 7.15 (s, 1H), 4.30-4.05 (m, 4H), 3.77 (s, 2H), 1.26 (t, J= 7.0 Hz, 3H).
References:
WO2018/237370,2018,A1 Location in patent:Paragraph 00194; 00197; 00198
911434-04-3
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1379312-86-3
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67443-38-3
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1379312-86-3
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