Methyl 2-chloro-4-methoxybenzo[d]thiazole-6-carboxylate synthesis
- Product Name:Methyl 2-chloro-4-methoxybenzo[d]thiazole-6-carboxylate
- CAS Number:1383740-05-3
- Molecular formula:C10H8ClNO3S
- Molecular Weight:257.69
955886-84-7
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Yield:1383740-05-3 89%
Reaction Conditions:
Stage #1: methyl 2-amino-4-methoxy-1,3-benzothiazole-6-carboxylatewith phosphoric acid;sodium nitrite in water at 0; for 1 h;
Stage #2: with copper(II) sulfate in water at 0;
Stage #3: with sodium chloride in water at 0 - 20; for 1 h;
References:
Tully, David C.;Rucker, Paul V.;Chianelli, Donatella;Williams, Jennifer;Vidal, Agnès;Alper, Phil B.;Mutnick, Daniel;Bursulaya, Badry;Schmeits, James;Wu, Xiangdong;Bao, Dingjiu;Zoll, Jocelyn;Kim, Young;Groessl, Todd;McNamara, Peter;Seidel, H. Martin;Molteni, Valentina;Liu, Bo;Phimister, Andrew;Joseph, Sean B.;Laffitte, Bryan [Journal of Medicinal Chemistry,2017,vol. 60,# 24,p. 9960 - 9973] Location in patent:supporting information
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