1H-1,2,4-Triazole-3-carboxylic acid, 1-(phenylmethyl)- synthesis
- Product Name:1H-1,2,4-Triazole-3-carboxylic acid, 1-(phenylmethyl)-
- CAS Number:138624-97-2
- Molecular formula:C10H9N3O2
- Molecular Weight:203.2
1097069-39-0
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138624-97-2
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Yield:138624-97-2 99%
Reaction Conditions:
Stage #1: 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid ethyl esterwith sodium hydroxide;water in ethanol; for 16 h;Heating / reflux;
Stage #2: with hydrogenchloride in water;
Steps:
12.B
To 1.2 g (6 mmol) of 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester in 10 ml of EtOH was added 1.4 ml (8 mmol) of 6 M sodium hydroxide solution. The mixture was stirred for 16 h after which time it was concentrated; then, 1 M hydrochloric acid solution was added and the resulting precipitate filtered affording 1.1 g (99%) of the title compound. MS: 204.1 (MH+).
References:
US2009/12063,2009,A1 Location in patent:Page/Page column 16
100-39-0
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138624-97-2
37 suppliers
$65.00/100mg