2-methyl-2,3-dihydro-1H-inden-1-amine hydrochloride (Mixture of diastereomers) synthesis

Yield:13943-76-5 85%

Reaction Conditions:

Stage #1: 2-methylindanone oximewith hydrogen;10% palladium on activated carbon in methanol;acetic acid;
Stage #2: with hydrogenchloride in ethanol;

Steps:

A3.b b. 1-(RS)(+-)-1-amino-2-methylindane hydrochloride

b. 1-(RS)(+-)-1-amino-2-methylindane hydrochloride A mixture of the above 2-methylindan-1-one oxime (9.5 g, 0.0589 mol) and palladium on charcoal catalyst (10% 1.0 g) in methanol and acetic acid was stirred under nitrogen.Hydrogen was then introduced until the theoretical amount was adsorbed.The catalyst was filtered off and the solvent evaporated in vacuo.Ethanolic hydrochloric acid solution (6N) was added, the solvent evaporated and the residue washed with a mixture of diethylether/acetone (10:1) and filtered to give 1-(RS)(+-)-1-amino-2-methylindane hydrochloride (9.7 g, yield 85%), mp. 241-242° C., purity 95%.

References:

US2004/157739,2004,A1 Location in patent:Page 14