ChemicalBook CAS DataBase List 2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole synthesis

7synthesis methods

Product Name:2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole
CAS Number:1401728-56-0
Molecular formula:C24H28N6O
Molecular Weight:416.52

33279-01-5 Synthesis

33279-01-5
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2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

1401728-56-0
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Yield:-

Steps:

Multi-step reaction with 7 steps
1.1: L-proline / ethanol / 16 h / 22 °C
2.1: hydrogen; palladium 10% on activated carbon / methanol; acetonitrile / 2 h / 25 °C / 2585.81 Torr
3.1: hydrazine / methanol / 3 h / 65 °C
4.1: acetic acid; hydrogenchloride; water / 43 h / 110 °C
5.1: 2,4,6-trimethyl-pyridine / N,N-dimethyl-formamide / 0.5 h / 23 °C / Inert atmosphere
5.2: 12 h / 23 °C / Inert atmosphere
6.1: p-toluenesulfonyl chloride; triethylamine / dichloromethane / 12 h / 23 °C
7.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C
7.2: 6 h / 20 °C

References:

NOVARTIS AG;MILTZ, Wolfgang;OBERHAUSER, Berndt;VAUPEL, Andrea;VELCICKY, Juraj;WEIGAND, Klaus;LELETI, Rajender Reddy;LIU, Yugang;DU, Zhengming US2012/252778, 2012, A1

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References

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References

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References