tert-Butyl 4-((2-(ethoxycarbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate synthesis
- Product Name:tert-Butyl 4-((2-(ethoxycarbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate
- CAS Number:1416051-61-0
- Molecular formula:C21H27NO5S
- Molecular Weight:405.51
![ethyl 3-hydroxybenzo[b]thiophene-2-carboxylate](/CAS/20200119/GIF/5556-20-7.gif)
5556-20-7
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109384-19-2
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1416051-61-0
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Yield:1416051-61-0 97%
Reaction Conditions:
Stage #1: ethyl 3-hydroxybenzothiophene-2-carboxylate;t-butyl 4-hydroxy piperidine-1-carboxylatewith triphenylphosphine in tetrahydrofuran; for 0.333333 h;Inert atmosphere;Mitsunobu Displacement;
Stage #2: with di-isopropyl azodicarboxylate in tetrahydrofuran at 0 - 20; for 1.58333 h;Inert atmosphere;
References:
Rackham, Mark D.;Brannigan, James A.;Moss, David K.;Yu, Zhiyong;Wilkinson, Anthony J.;Holder, Anthony A.;Tate, Edward W.;Leatherbarrow, Robin J. [Journal of Medicinal Chemistry,2013,vol. 56,# 1,p. 371 - 375] Location in patent:supporting information
4892-02-8
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$23.00/1g
1416051-61-0
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