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4-AMINO-N-[4-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]BENZENESULFONAMIDE synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 67 percent / sodium acetate, acetic acid / 12 h / 100 - 110 °C
2: 52 percent / 10percent aq. NaOH / 6 h / 100 °C

References:

Gerus, I. I.;Vdovenko, S. I.;Gorbunova, M. G.;Kukhar', V. P. [Chemistry of Heterocyclic Compounds,1991,vol. 27,# 4,p. 398 - 406][Khimiya Geterotsiklicheskikh Soedinenii,1991,# 4,p. 502 - 511]