5-chloro-3-(2-methoxypropan-2-yl)-1,2,4-thiadiazole synthesis

Yield:-

Reaction Conditions:

with sodium hydroxide in dichloromethane;water at -15 - 20; for 3 h;

Steps:

I.C 5-chloro-3-(2-methoxypropan-2-yl)-1,2,4-thiadiazole

Step C: 2-Methoxy-2-methylpropanimidamide hydrochloride (2.0 g, 13 mmol) and trichloromethyl hypochlorothioite (1.3 mL, 12 mmol) were dissolved in CH₂CI₂ (15 mL) and cooled to -15 °C. Sodium hydroxide (2.6 g, 66 mmol) dissolved in water (5 mL) was added dropwise and the reaction was stirred at ambient temperature for 3 hours. The reaction was diluted with CH₂C1₂ (15 mL), washed with water, dried over MgS0₄, filtered and concentrated in vacuo to afford crude 5-chloro-3-(2-methoxypropan-2-yl)-l,2,4-thiadiazole (2.1 g, 11 mmol, 91 > yield) as an orange oil.

References:

WO2013/66869,2013,A1 Location in patent:Paragraph 00394