Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
1445586-50-4

Benzoic acid, 4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]-, sodium salt synthesis

6synthesis methods
6-Pteridinepropanoic acid, 2,4-diamino-.alpha.-(4-carboxyphenyl)-.alpha.-2-propyn-1-yl-

146464-92-8
32 suppliers
$505.42/5MG

Benzoic acid, 4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]-, sodium salt

1445586-50-4
12 suppliers
inquiry

-

Yield:1445586-50-4 50.3%

Reaction Conditions:

Stage #1: 4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid in dimethyl sulfoxide at 110 - 115;
Stage #2: with water;sodium hydride in isopropyl alcohol at 50 - 55;

Steps:

8 10-Propargyl-4-deoxy-4-amino-10-deazapteroic Acid sodium salt

A solution of 10-Propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic Acid (40 g) in DMSO (400 mL) was added to preheated DMSO (1400 mL) at 110-115° C and stirred for 20-30 min. The reaction was monitored by HPLC and upon completion; the reaction mixture was concentrated to dryness under vacuum below 90 °C. IPA (600 mL) was added to the residue and heated to 50-55 °C for 2-3 hours, subsequently cooled to 20-25 °C and vacuum filtered the solid. For preparing sodium salt of the acid the solid obtained was added to DM water (100 mL), followed by drop wise addition of aqueous NaOH solution (6.11 g NaOH in 300 mL DM water) at 10-15° C. The reaction mass was further cooled to 0-5 °C and stirred for 2- 3 hours. The solid was filtered under vacuum. The solid obtained was purified by dissolving in a mixture of DM water (320 mL) and IPA (640 mL) at 75-85 °C. The clear solution was filtered through Celite bed (20 g). The filtrate was cooled slowly to 0-5 °C and stirred for 1-2 hours. The solid obtained was filtered and dried under vacuum at 60-65 °C to give 19 g (50.3 %) of the title compound. Purity: 99.3 %.

References:

WO2014/16740,2014,A2 Location in patent:Page/Page column 24

Benzoic acid, 4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]-

146464-93-9
45 suppliers
inquiry

Benzoic acid, 4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]-, sodium salt

1445586-50-4
12 suppliers
inquiry

References
4-METHOXYCARBONYLMETHYL-BENZOIC ACID METHYL ESTER

52787-14-1
140 suppliers
$12.00/1g

Benzoic acid, 4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]-, sodium salt

1445586-50-4
12 suppliers
inquiry

References
α-propargylhomoterephthalic acid dimethyl ester

146464-90-6
59 suppliers
inquiry

Benzoic acid, 4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]-, sodium salt

1445586-50-4
12 suppliers
inquiry

References
6-Pteridinepropanoic acid, 2,4-diaMino-α-[4-(Methoxycarbonyl)phenyl]-α-2-propyn-1-yl-, Methyl ester

146464-91-7
15 suppliers
inquiry

Benzoic acid, 4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]-, sodium salt

1445586-50-4
12 suppliers
inquiry

References