tert-butyl (R)-7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate synthesis
- Product Name:tert-butyl (R)-7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
- CAS Number:1453316-08-9
- Molecular formula:C11H19NO4
- Molecular Weight:229.27
![5-Oxa-2-azaspiro[3.4]oct-6-ene-2-carboxylic acid, 1,1-dimethylethyl ester](/CAS/20210305/GIF/1446012-65-2.gif)
1446012-65-2
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1453316-08-9
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Yield:1453316-08-9 74%
Reaction Conditions:
Stage #1: tert-butyl 5-oxa-2-azaspiro[3.4]oct-6-ene-2-carboxylatewith L-diisopinocampheylborane in tetrahydrofuran at -78 - 50; for 40 h;Inert atmosphere;Schlenk technique;
Stage #2: with dihydrogen peroxide;potassium hydroxide in tetrahydrofuran;water at 0 - 20; for 0.5 h;Inert atmosphere;Schlenk technique;enantioselective reaction;
References:
Li, Dong Bo;Rogers-Evans, Mark;Carreira, Erick M. [Organic Letters,2013,vol. 15,# 18,p. 4766 - 4769] Location in patent:supporting information
398489-26-4
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1453316-08-9
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398489-51-5
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1453316-08-9
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