Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate synthesis
- Product Name:Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
- CAS Number:147118-35-2
- Molecular formula:C31H39O4PSi
- Molecular Weight:534.7
91424-40-7
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Yield:-
Steps:
Multi-step reaction with 5 steps
1.1: n-butyllithium; triphenylmethane; (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol / toluene; hexane; tetrahydrofuran / 2 h / -78 °C
1.2: 3 h
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate
3.1: sodium methylate / 3 h / 0 - 5 °C / Cooling with ice
3.3: pH 6.5
4.1: triethylamine / hexane / 3 h / -40 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 °C
5.2: 3 h / -78 °C
References:
MATRIX LABORATORIES LTD.;SETHI, Madhuresh, Kumar;MAHAJAN, Sanjay;RAWAT, Vijendra, Singh;MARA, Bhairaiah;VEERA, Upendra, Nath;DATTA, Debashish WO2011/141934, 2011, A1
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